Contribution of α-Gustducin to Taste-guided Licking Responses of Mice
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چکیده
منابع مشابه
Partial Rescue of Taste Responses of α-Gustducin Null Mice by Transgenic Expression of α-Transducin
The transduction of responses to bitter and sweet compounds utilizes guanine nucleotide binding proteins (G proteins) and their coupled receptors. α-Gustducin, a transducin-like G protein α-subunit, and rod α-transducin are expressed in taste receptor cells. α-Gustducin knockout mice have profoundly diminished behavioral and electrophysiological responses to many bitter and sweet compounds, alt...
متن کاملRevised Manuscript Fat and Carbohydrate Preferences in Mice: The Contribution of α-Gustducin and Trpm5 Taste Signaling Proteins
Short Title: Fat and Carbohydrate Preferences in Gustducin and Trpm5 Knockout Mice
متن کاملFat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins.
Trpm5 and alpha-gustducin are key to the transduction of tastes of sugars, amino acids, and bitter compounds. This study investigated the role of these signaling proteins in the preference for fat, starch, and starch-derived polysaccharides (Polycose), using Trpm5 knockout (Trpm5 KO) and alpha-gustducin knockout (Gust KO) mice. In initial two-bottle tests (24 h/day), Trpm5 KO mice showed no pre...
متن کاملFat and carbohydrate preferences in mice: the contribution of -gustducin and Trpm5 taste-signaling proteins
Sclafani A, Zukerman S, Glendinning JI, Margolskee RF. Fat and carbohydrate preferences in mice: the contribution of -gustducin and Trpm5 taste signaling proteins. Am J Physiol Regul Integr Comp Physiol 293: R1504–R1513, 2007. First published July 25, 2007; doi:10.1152/ajpregu.00364.2007.—Trpm5 and -gustducin are key to the transduction of tastes of sugars, amino acids, and bitter compounds. Th...
متن کاملUmami Taste Responses Are Mediated by -Transducin and -Gustducin
Wei He,1* Keiko Yasumatsu,3* Vijaya Varadarajan,1 Ayako Yamada,3 Janis Lem,4 Yuzo Ninomiya,3 Robert F. Margolskee,2 and Sami Damak1 1Department of Physiology and Biophysics and 2Howard Hughes Medical Institute, The Mount Sinai School of Medicine, New York, New York 10029, 3Section of Oral Neuroscience, Kyushu University, Fukuoka 812-8582, Japan, and 4Department of Ophthalmology and Program in G...
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ژورنال
عنوان ژورنال: Chemical Senses
سال: 2005
ISSN: 1464-3553,0379-864X
DOI: 10.1093/chemse/bji025